How can AI move from assisting with tasks to advancing scientific discovery and creating measurable business value? Drawing on biomedicine, Jorge explores the capabilities and organizational choices required: models that integrate multiple forms of evidence and treat time as a first-class dimension, experimentation that tests predictions and fit-for-purpose evaluations that establish whether performance translates into useful outcomes. Hear how leaders can redesign workflows, assign accountability and connect investment decisions to evidence of impact as increasingly capable AI systems enter the enterprise.